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Synthetic polymers have contributed significantly to the development of advanced scaffolds for load bearing tissue engineering applications. Despite this, there is still a need to create scaffolds that can simultaneously present multiple biophysical and biochemical properties to better mimic native cellular environments. Polyglycidol has been shown to be a biocompatible polyether polyol, that forms different, sometimes complex, polymeric architectures. Furthermore, it has multiple hydroxyl groups that are capable of numerous chemical modifications. However, little is known about the biocompatibility of modified polyglycidols and their resulting 3-D network. The overarching hypothesis for this project is that changes in the mechanical, structural, and compositional cues within a polyglycidol-based network can be tailored to influence cell responses. Therefore, as a crucial first step, we investigated the biocompatibility of functionalized polyglycidols, and the swelling, degradation, and mechanical properties of polyglycidol based hydrogels. Ongoing studies aim to show that a defined subset of biophysical and biochemical cues can be incorporated simultaneously within the polyglycidol hydrogel. Such an advanced scaffold would allow us to study the synergistic effects of various chemical and physical cues on cellular behavior.